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Literature summary extracted from

  • Mentlein, R.; Hattermann, K.; Hemion, C.; Jungbluth, A.; Held-Feindt, J.
    Expression and role of the cell surface protease seprase/fibroblast activation protein-alpha (FAP-alpha) in astroglial tumors (2011), Biol. Chem., 392, 199-207.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.B28 cell surface
-
 Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B28 alpha2-antiplasmin + H2O Homo sapiens
-
 ?
-
 ?
3.4.21.B28 Gelatin + H2O Homo sapiens
-
 ?
-
 ?
3.4.21.B28 pre-digested collagen + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B28 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B28 astrocytoma cell
-
 Homo sapiens
-
3.4.21.B28 astroglial tumor cell
-
 Homo sapiens
-
3.4.21.B28 glioblastoma cell
-
 Homo sapiens
-
3.4.21.B28 glioblastoma cell glioma stem-like cell, isolated from a solid glioblastoma in a long term culture, low expression Homo sapiens
-
3.4.21.B28 glioma cell
-
 Homo sapiens
-
3.4.21.B28 U-118MG cell
-
 Homo sapiens
-
3.4.21.B28 U-138 cell
-
 Homo sapiens
-
3.4.21.B28 U-343 MG-A cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B28 alpha2-antiplasmin + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.B28 Gelatin + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.B28 additional information does not cleave native human collagens, fibronectin or laminin Homo sapiens ?
-
 ?
3.4.21.B28 additional information FAP-alpha is an endopeptidase cleaving large protein with Gly(2)-Pro(1)-cleaving specificity Homo sapiens ?
-
 ?
3.4.21.B28 pre-digested collagen + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B28 FAP-alpha
-
 Homo sapiens
3.4.21.B28 fibroblast activation protein-alpha
-
 Homo sapiens
3.4.21.B28 seprase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.21.B28 Homo sapiens FAP-alpha is considerably induced upon differentiation with 10% fetal calf serum, FAP-alpha is elevated in glioblastomas and increases upon tumor stem cell differentiation up

General Information

EC Number General Information Comment Organism
3.4.21.B28 malfunction siRNA knockdown of FAP-alpha in a glioma cell line shows decreased invasion through brain extracellular matrix proteoglycan brevican and denatured collagen Homo sapiens